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. 2001 Aug 1;534(Pt 3):813–825. doi: 10.1111/j.1469-7793.2001.00813.x

Figure 7. External calcium does not rapidly block the capsaicin-gated current in DRG neurons.

Figure 7

A, elevating [Ca2+]o from zero (5 mm EGTA) to 1.8 mm did not rapidly reduce the amplitude of capsaicin-gated current in nociceptive neurones. Mean suppression in 1.8 mm Ca2+ was 5.05 (± 1.1)-fold (n = 9). Time constant of the recovery on return to zero Ca2+ was 122 ± 37 s. Intracellular solution contained 0.2 mm EGTA. B, rapid elevation of [Ca2+] from zero (5 mm EGTA) to 1.8 mm Ca2+ had no immediate effect on capsaicin-gated current (current decreased by 0.008 (± 0.012)-fold, n = 7). Internal calcium in this experiment was stabilized with 5 mm BAPTA added to the patch pipette.