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. 2001 Aug 1;534(Pt 3):849–859. doi: 10.1111/j.1469-7793.2001.00849.x

Figure 1. Nociceptin produces an outward current in both primary and secondary RVM neurons.

Figure 1

A, U-69593 (U69, 300 nm) produced a nor-BNI (300 nm)-sensitive outward current and met-enkephalin (ME, 10 μm) produced no currents in a primary neuron. B, met-enkephalin but not U-69593 produced an outward current in a secondary neuron. Nociceptin (Nocic, 300 nm) produced an outward current in both primary (A) and secondary (B) neurons. Nocistatin (Nstat, 1 μm) and prepronociceptin154-181 (ppOFQ, 300 nm) produced no currents in the secondary neuron (B). Nalx, naloxone (1 μm).