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. 2001 Aug 1;534(Pt 3):849–859. doi: 10.1111/j.1469-7793.2001.00849.x

Figure 6. Nociceptin inhibits evoked but not miniature GABAergic synaptic currents in RVM neurons.

Figure 6

A, time course of the amplitude of evoked IPSCs (eIPSC Ampl) during application of nociceptin (Nocic, 300 nm), then TTX (300 nm). Each point is the mean of 3 consecutive evoked IPSCs. B, averaged raw traces of evoked IPSCs from before (Control), during (Nocic) and after (Wash) application of nociceptin, then after addition of TTX (average of 10-20 IPSCs). C, time course of mIPSC rate in the presence of TTX (300 nm) during superfusion of nociceptin (300 nm), then met-enkephalin (ME, 10 μm) and addition of naloxone (Nalx, 1 μm), then bicuculline (Bicuc, 30 μm). D, averaged raw traces of mIPSCs before (Control) and during superfusion of nociceptin and met-enkephalin. A-D are taken from one neuron in the presence of CNQX (3 μm) and strychnine (3 μm).