Figure 2. Alignment of predicted amino acid sequences from the rat SK3 gene (rSK3), the human SK3 gene (hSK3, accession number NM_002249) and the rat SK2 (accession number U69881) and SK1 (accession number AF000973) genes.

Boxes highlight amino acids that are conserved between rSK3 and one or more of the other sequences. The human and rat genes show greater similarity than originally reported, particularly at the amino-terminal end. Putative transmembrane elements (S1-6) and the potassium channel pore-forming ‘P-loop’ are indicated with bars. This alignment was made using the BLOSUM weight matrix with a gap open penalty of 8.0 and a gap extension penalty of 2.0.