Table 1.
Activation parameters of iK,total, putative iK,r and putative iK,s
| Current | Tissue | V1/2 (mV) | k (mV) | Vh (mV) | Temperature(°C) | Reference |
|---|---|---|---|---|---|---|
| iK,total | Rabbit SA node | −20.2 ± 0.8 | 9.3 ± 0.7 | −60 | 35 | This study (n = 21) |
| iK,total | Rabbit SA node | −25.1 | 7.4 | −43 | 36–37 | Shibasaki (1987) |
| iK,total | Rabbit SA node | −14.5 | 11.5 | −50 | 36–37 | Lei & Brown (1996) |
| Putative iK,r | ||||||
| E-4031 sensitive | Rabbit SA node | −27.7 ± 1.1 | 5.9 ± 1.1 | −60 | 35 | This study (n = 10) |
| 293B insensitive | Rabbit SA node | −34.4 ± 1.5 | 6.0 ± 1.3 | −60 | 35 | This study (n = 13) |
| E-4031 sensitive | Rabbit SA node | −23.2 | 10.6 | −60 | 35 | Ono & Ito (1995) |
| Dofetilide sensitive | Rabbit SA node | −17.4 | 9.7 | −50 | 36–37 | Lei & Brown (1996) |
| E-4031 sensitive | Guinea-pig atrium | −19.3 | 5.2 | −40 | 35 | Sanguinetti & Jurkiewicz (1991) |
| E-4031 sensitive | Guinea-pig ventricle | −21.5 | 7.5 | −40 | 35 | Sanguinetti & Jurkiewicz (1990) |
| Putative iK,s | ||||||
| E-4031 insensitive | Rabbit SA node | +3.0 ± 1.2 | 15.9 ± 1.3 | −60 | 35 | This study (n = 13) |
| 293B sensitive | Rabbit SA node | −3.7 ± 1.2 | 13.6 ± 1.3 | −60 | 35 | This study (n = 10) |
| Dofetilide insensitive | Rabbit SA node | +15.6 | 14.7 | −50 | 36–37 | Lei & Brown (1996) |
| E-4031 insensitve | Guinea-pig atrium | +24.0 | 15.7 | −40 | 35 | Sanguinetti & Jurkiewicz (1991) |
| E-4031 insensitive | Guinea-pig ventricle | +15.7 | 12.7 | −40 | 35 | Sanguinetti & Jurkiewicz (1990) |
Vh, holding potential; k, slope factor; SA, sinoatrial.