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Effect of 0.1 μm E-4031 on action potential parameters of large SA node cells
| APA (mV) | APD100 (ms) | MDP (mV) | DDR (mV s−1) | Cycle length (ms) | |
|---|---|---|---|---|---|
| Control | 84 ± 6 | 140 ± 11 | −66 ± 4 | 179 ± 22 | 250 ± 31 |
| E-4031 | 68 ± 6* | 187 ± 7* | −56 ± 6* | 120 ± 15* | 309 ± 24* |
Cm, 46 ± 3 pF, range 39–54 pF, n = 6. APA, action potential amplitude; APD100, action potential duration at 100% repolarisation; MDP, maximum diastolic potential; DDR, diastolic depolarisation rate
P < 0.05 vs. Control.
