Figure 11. Effects of changes in the control properties of glycolysis on pH and metabolite changes during ischaemic exercise.

The figure shows the results of a simulation of two hypothetical cases: assuming glycolysis linear with time, and assuming glycolysis is constant. We assume that the total amount of lactate produced, the time taken and the rate of ATP turnover are the same as measured. Results are obtained by numerical solution of eqns (38)-(40). Left-hand panels show the glycolytic rate (as a fraction of total ATP turnover rate) plotted against exercise time (A), the total amount of glycolytic ATP synthesised (B) and the fall in PCr (C) (the latter two quantities scaled to ATP turnover). Right-hand panels show the changes in pH (D), PCr concentration (E) and ADP concentration (F). The theoretical lines are as labelled. The observed data are shown by filled circles (means ±s.e.m.).