Table 1.

Comparison of the magnitude and time course of effects of AA and PMA in human eosinophils

	τact	τtail	IH	Ie (pA)
AA/control	0.25 ± 0.12 (7)	1.0 ± 0.4 (6)†	4.6 ± 1.5 (7)	−7.4 ± 3.8 (22)
PMA/control	0.24 ± 0.09 (12)	5.4 ± 3.4 (14)	4.7 ± 2.8 (12)	−6.0 ± 2.8 (23)
t1/2 AA (min)	0.1 ± 0.2 (7)†	—	0.7 ± 1.1 (7)	1.2 ± 1.1 (17)*
t1/2 PMA (min)	1.0 ± 0.6 (12)	1.6 ± 0.7 (14)	2.0 ± 1.5 (12)	2.5 ± 2.1 (17)

The average ratio of each parameter, except I_e, measured after treatment with 3–10 μm AA to its value before treatment. Mean ± S.D. is given for (n) observations. Usually I_H and τ_act were measured during pulses to +40 or +60 mV, and τ_tail and I_e at −60 mV. I_e is taken as the average peak increase in inward current after PMA. The t_1/2 value is the time required for the change to reach half-completion. The difference between AA and PMA is significant at

^*P < 0.05

^†P < 0.01 by Student's t test. The PMA values are for human eosinophils, taken from DeCoursey et al. (2001).