Figure 5. The effects of CGP 55845A alone on the EPSPM and IPSPB.
A, synaptic traces of representative EPSPMs recorded in control (a) and in the presence of 1 μm CGP 55845A (B). Note that following stimulation, the neurone responds with a hyperpolarization (IPSPB) followed by a small EPSPM, and following the addition of CGP 55845A the IPSPB is inhibited and the EPSPM enhanced. The membrane potential of this neurone was maintained at -64 mV using DC injection. B, mean peak amplitude of successive EPSPMs and IPSPBs, for pooled data (n = 3), versus time illustrating the enhancement of the EPSPM and the depression of the IPSPB by CGP 55845A. The bar above the graph indicates the duration for which CGP 55845A was applied. C, bar graphs illustrating pooled data for the effect of 1 μm CGP 55845A on the amplitude of the EPSPM and IPSPB (n = 3).