Figure 6. Kinetic comparison of the IPSP_B with the EPSP_M.

Traces are an EPSP_M (top) recorded in the presence of GABA and glutamate receptor antagonists NBQX, CGP 40116, picrotoxin and CGP 55845A and an IPSP_B (bottom) in the presence of NBQX, CGP 40116, picrotoxin and the GABA uptake inhibitor NNC 05-711. The membrane potentials of the neurones are -64 mV and -62 mV, respectively. Note that even in the presence of an inhibitor of GABA uptake, the isolated IPSP_B peaks prior to the start of the depolarizing EPSP_M and that the hyperpolarizing response is all but complete by the peak of the EPSP_M. The dotted line indicates the time of the peak of the isolated IPSP_B, which was evoked in the presence of the GABA uptake inhibitor.