Figure 2. Transient- and transport-associated currents in wild-type and mutated GAT1.
Currents in response to voltage-clamp steps to −120, −80, 0 and +40 mV (from Vh = −40 mV) are shown for two oocytes expressing wild-type (Aa and Ab) and K448E rGAT1 (Ba and Bb) in the absence (left column) and presence (right column) of 100 μm GABA. C, I–V curves for transport-associated currents (□, wild-type, n = 13; ○, K448E, n = 11; data from three batches).