Table 1. UV effect on dose–response relationships of recombinant GABAA and GABAC receptors.
Before UV | After UV | ||||||
---|---|---|---|---|---|---|---|
Subunit combinations | Imax (nA) | EC50 (μm) | Hill coeff | Imax (nA) | EC50 (μm) | Hill coeff | Number of oocytes |
α1β2γ2 | 922 ± 460 | 44.2 ± 3.3 | 1.6 ± 0.1 | 1093 ± 601 | 23.2 ± 3.1 | 1.3 ± 0.1 | 3 |
α1β2 | 178 ± 77 | 5.9 ± 1.4 | 1.1 ± 0.1 | 375 ± 200 | 1.5 ± 0.1 | 1.1 ± 0.1 | 3 |
β2γ2 | 380 ± 91 | 51.3 ± 9.3 | 1.3 ± 0.2 | 400 ± 103 | 25.1 ± 2.8 | 1.1 ± 0.1 | 4 |
ρ1 | 182 ± 91 | 1.0 ± 0.1 | 2.8 ± 0.1 | 197 ± 96 | 1.2 ± 0.1 | 2.0 ± 0.2 | 3 |