Table 1.

Effects of low-dose acetazolamide on respiratory parameters during hyperoxia

	Control	Acetazolamide	P
B (kPa)	2.91 ± 0.57	0.78 ± 1.9	0.005
SC (l min-1 kPa-1)	0.45 ± 0.16	0.27 ± 0.13	0.001
SP (l min-1 kPa-1)	0.09 ± 0.07	0.06 ± 0.05	0.123
τP (s)	5.91 ± 4.28	7.27 ± 5.76	0.741
τon (s)	83.60 ± 47.60	88.56 ± 25.28	0.756
τoff (s)	108.65 ± 45.04	128.98 ± 46.86	0.362
(kPa)	0.05 ± 0.57	0.43 ± 0.81	0.029
(kPa)	47.40 ± 3.62	46.95 ± 5.19	0.633

Parameter values obtained from the optimal fits in the analysis of DEF runs performed during hyperoxia (32 control runs and 27 runs after acetazolamide). B, the apnoeic threshold or X-intercept of the ventilatory CO₂ response curve. S_C and S_P, the CO₂ sensitivities of the central and peripheral chemoreflex loops, respectively. τ_p, time constant of the peripheral chemoreflex loops. τ_on and τ_off, central time constants of responses to CO₂ on-and off transients, respectively. , arterial–end-tidal difference.