Table 2.

Effects of low-dose acetazolamide on respiratory parameters during hypoxi

	Control	Acetazolamide	P
B(kPa)	1.59 ± 1.22	−0.70 ± 2.99	0.030
SC (l min-1 kPa-1)	0.40 ± 0.16	0.26 ± 0.13	0.019
Sp (l min-1 kPa-1)	0.16 ± 0.06	0.07 ± 0.05	0.002
τp (s)	4.26 ± 4.92	5.12 ± 4.04	0.693
τon (s)	73.68 ± 37.63	60.37 ± 22.79	0.269
τoff (s)	104.53 ± 50.35	126.82 ± 65.84	0.469
(kPa)	−0.10 ± 0.57	0.39 ± 0.75	0.009
(kPa)	8.02 ± 0.30	8.02 ± 0.66	0.986

Parameter values obtained from the optimal fits in the analysis of DEF runs performed during hypoxia (32 control runs and 29 runs after acetazolamide). B, the apnoeic threshold or X-intercept of the ventilatory CO₂ response curve. S_C and S_p, the CO₂ sensitivities of the central and peripheral chemoreflex loops, respectively. τ_p, time constant of the peripheral chemoreflex loop. τ_on and τ_off, central time constants of responses to CO₂ on-and off transients, respectively. , arterial–end-tidal difference.