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. 2001 Dec 1;537(Pt 2):453–465. doi: 10.1111/j.1469-7793.2001.00453.x

Figure 3. Inhibition of GABA-elicited currents by PS.

Figure 3

A, in a control DGC, current elicited by 30 μm GABA compared to that elicited by co-application of 10 and 100 μm pregnenolone sulfate (PS) and GABA. The peak current elicited by GABA was strongly inhibited by 30 and 100 μm PS. B, in an epileptic DGC, inhibition of GABA currents by the same concentrations of PS was not different from the control cell. C, PS concentration-DGC GABAA receptor current relationships. PS concentration- response curves were obtained for control (□, n = 14) and epileptic DGCs (○, n = 10).