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. 2001 Dec 1;537(Pt 2):453–465. doi: 10.1111/j.1469-7793.2001.00453.x

Figure 6. Zn2+ inhibition of GABA-elicited currents.

Figure 6

A, co-application of 30 and 100 μm Zn2+ with 30 μm GABA caused inhibition of 30 μm GABA-elicited currents in a control DGC, B, inhibition was more profound in an epileptic DGC. C, Zn2+ concentration- DGC GABAA receptor current relationships. Concentration-response curves were obtained for control (○, n = 11) and epileptic DGCs (□, n = 14). Note the increased potency of Zn2+ in inhibiting of GABAA receptor currents, evoked in epileptic DGCs. The maximal enhancement of GABAA receptor currents remained similar for control and epileptic cells.