Figure 1.

Changes during and after exercise in interstitial lactate and dialysate ammonia concentrations in biceps muscle of six patients with McArdle's disease and six healthy matched controls. Changes are from pre-exercise resting levels to: (1) exercise, (2) the first 4 min of recovery from exercise and (3) at rest 1 h following static arm flexor exercise, in probes from which data could be obtained at all time points. The number of probes evaluated at all time points was (McArdle/control) 6/7 for ammonia and 4/3 for lactate. Ammonia results do not include data from the patient with combined myophosphorylase and myoadenylate deaminase deficiency. Ammonia data from this patient are shown separately in Table 2. Values are means ±s.e.m.† Significantly different change from pre-exercise rest in all patients vs. controls. * Significantly different change from pre-exercise rest in all subjects.