Table 3.

MSNA, heart rate and blood pressure (BP) responses to static arm flexor exercise at 30% MVC

		Exercise
	Rest	0.5 min	1.0 min	1.5 min	2.0 min	Exhaustion or 3 min	Recovery	ΔMax
MSNA (bursts min-1)
McArdle	25 ± 5	28 ± 5	33 ± 6	44 ± 7 †	44 ± 8 †	47 ± 7 †	31 ± 6	22 ± 6 †
Controls	20 ± 3	20 ± 4	24 ± 4	25 ± 5	23 ± 4	30 ± 4	19 ± 4	10 ± 2
McArdle + MADD	22	34	34	41	46	41	25	24
MSNA (total activity)
McArdle	—	25 ± 27	48 ± 22	130 ± 64	128 ± 77 †	164 ± 71 †	29 ± 15 †	164 ± 71 †
Controls	—	0 ± 21	14 ± 16	22 ± 23	28 ± 25	59 ± 19	4 ± 22	59 ± 19
McArdle + MADD	—	72	74	92	159	92	14	159
Heart rate (beats min-1)
McArdle	70 ± 3	78 ± 5	81 ± 5	85 ± 5	89 ± 7	90 ± 6	75 ± 4	20 ± 3
Controls	66 ± 2	84 ± 3	84 ± 2	86 ± 2	89 ± 2	92 ± 2	67 ± 4	25 ± 2
McArdle + MADD	66	69	73	90	93	93	79	27
Mean BP (mmHg)
McArdle	108 ± 12	130 ± 16	135 ± 17	142 ± 14	143 ± 14	160 ± 13 †	132 ± 13	47 ± 7 †
Controls	122 ± 11	134 ± 12	142 ± 15	147 ± 14	155 ± 14	160 ± 13	125 ± 17	38 ± 4
McArdle + MADD	117	134	138	152	160	160	138	43

Data are from five patients with myophosphorylase deficiency (McArdle), six healthy sedentary subjects (Controls) and one patient with combined myophosphorylase and myoadenylate deaminase deficiency (McArdle + MADD). MSNA is expressed both as bursts per min and total activity (% change from rest). ΔMax, maximal increase from Rest to Exercise. The separately shown results in the myophosphorylase- and myoadenylate-deficient patient are also integrated in the grouped data for all McArdle patients. Values are means ±s.e.m.

^†Significantly greater increase from rest in McArdle patients compared to controls (P <0.05).