Table 1.
THC Dose effect & | VEH | 0.3 mg/kg CBD | 3 mg/kg CBD | 30 mg/kg CBD |
---|---|---|---|---|
ED50 mg/kg (CLI) | 0.8 (0.6 –1.2) | 1.1 (0.6 – 2.1) | 0.7 (0.4 – 1.3) | 1.1 (0.53 – 2.2) |
Potency Ratio CBD : THC (CL) | ND | 0.8 (0.4 – 1.4) | 1.1 (0.4 – 2.8) | 0.8 (0.3 – 1.7) |
ED50 values are derived from the THC dose effect (0.3, 1, 3 mg/kg) plus the respective dose of CBD (column headings). Potency ratios (and 95% confidence limits [CL]) for each drug were calculated with respect to the ED50 for THC (VEH column).
indicates that potency for the measure is significantly different than potency for producing THC discriminative stimulus when administered with vehicle. (p<0.05). ND=not determined.