Skip to main content
. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Drug Alcohol Depend. 2008 Apr 1;94(1-3):191–198. doi: 10.1016/j.drugalcdep.2007.11.017

Table 1.

ED50s and potency ratios for THC and combinations of THC and CBD in rats trained to discriminate 3 mg/kg THC from vehicle

THC Dose effect & VEH 0.3 mg/kg CBD 3 mg/kg CBD 30 mg/kg CBD
ED50 mg/kg (CLI) 0.8 (0.6 –1.2) 1.1 (0.6 – 2.1) 0.7 (0.4 – 1.3) 1.1 (0.53 – 2.2)
Potency Ratio CBD : THC (CL) ND 0.8 (0.4 – 1.4) 1.1 (0.4 – 2.8) 0.8 (0.3 – 1.7)

ED50 values are derived from the THC dose effect (0.3, 1, 3 mg/kg) plus the respective dose of CBD (column headings). Potency ratios (and 95% confidence limits [CL]) for each drug were calculated with respect to the ED50 for THC (VEH column).

*

indicates that potency for the measure is significantly different than potency for producing THC discriminative stimulus when administered with vehicle. (p<0.05). ND=not determined.