Figure 1. Upregulation of MMP-9 in the DRG after spinal nerve ligation (SNL).
(a) Gelatin zymography shows a time course of MMP-9 and MMP-2 activity in the injured L5 DRG of SNL rats. Right panel shows intensity of specific MMP bands, expressed as fold change over non-injured control. * p<0.05, compared to control (n=5). (b) MMP-9 Western blotting in the L5 DRG of sham and SNL rats. Right panel, quantification of MMP-9 band intensity (* p<0.05, n=3). (c) MMP-9 immunohistochemistry in the L5 DRG of control and SNL rats. Note that MMP-9 is expressed in DRG neurons. Scale, 50 μm.