Table 1.

Clinical characteristics of family members.

Pedigree Number	Age at evaluation (yrs)	Age at onset (yrs)	Rhythm	Symptoms	Echo	Signal averaged P-wave (msec)-	LA size (mm)	EF	Therapy
Affected and haplotype carriers
I: 1	75	41	Chronic lone AF	Yes	Normal	-	45	0.60	Rate control
I: 2	Deceased	NA	Chronic AF	Yes	NA	-	NA	NA	Rate control
II: 10	58	42	Paroxysmal AF	Yes	Normal	190	46	0.55	AAD
II: 16	66	32	Paroxysmal AF	Yes	LVH	189	44	0.60	AAD
II: 18	68	32	Paroxysmal lone AF	Yes	Normal	200	40	0.60	Rate control
II: 20	70	30	Paroxysmal AF	Yes	LVH	180	42	0.55	AAD
III: 1	38	18	Paroxysmal lone AF	Yes	Normal	210	NA	0.65	Rate control
III: 4	32	-	NSR	Yes	Normal	250	38	0.65	NA
III: 6	34	18	Paroxysmal lone AF	Yes	Normal	198	44	0.65	AAD
IV: 1	22	-	NSR	No	Normal	210	39	0.65	NA
Unaffected (individuals without a disease haplotype)
II: 1	52	-	NSR	No	Normal	112	36	0.60	-
II: 2	54	-	NSR	No	Normal	104	34	0.60	-
II: 3	57	-	NSR	No	Normal	108	38	0.55	-
II: 4	61	-	NSR	No	Normal	107	40	0.60	-
II: 5	64	-	NSR	No	Normal	112	38	0.50	-
II: 6	65	-	NSR	No	Normal	141	36	0.55	-
II: 7	67	-	NSR	No	Normal	105	37	0.55	-
II: 8	72	-	NSR	No	Normal	117	36	0.50	-
II: 9	55	-	NSR	No	Normal	118	38	0.60	-
II: 13	75	-	NSR	No	LVH	134	40	0.65	-
II: 14	72	-	NSR	No	Normal	140	39	0.55	-
II: 15	64	-	NSR	No	Normal	110	36	0.65	-
II: 21	63	-	NSR	No	Normal	125	40	0.60	-
II: 22	62	-	NSR	No	Normal	118	38	0.55	-
III: 2	60	-	NSR	No	Normal	120	36	0.60	-
III: 3	34	-	NSR	No	Normal	105	38	0.60	-
III: 5	36	-	NSR	No	Normal	110	38	0.60	-

AF, atrial fibrillation; AAD, antiarrhythmic drug; EF, ejection fraction; LA, left atrial; LVH, left ventricular hypertrophy; NA, not available.