Table 3.
Exposure-related microscopic lesions in rats exposed to MSC
| Incidence in males (No. with lesion/No. evaluated) | Incidence in females (No. with lesion/No. evaluated) | |||||||
|---|---|---|---|---|---|---|---|---|
| MSC dose (mg/kg/day) | 0 | 0.5 | 1.0 | 2.0 | 0 | 0.5 | 1.0 | 2.0 |
| Liver | ||||||||
| -- Peliosis hepatis | 0/20 | 0/20 | 0/20 | 3/20 | 0/20 | 0/20 | 0/20 | 15/20 b |
| -- Hepatocellular degeneration | 0/20 | 0/20 | 0/20 | 6/20 b | 0/20 | 3/20 | 7/20 b | 18/20 b |
| -- Subacute inflammation | 0/20 | 0/20 | 0/20 | 0/20 | 0/20 | 1/20 | 3/20 | 9/20 b |
| Skin | ||||||||
| -- Hair follicle atrophy | 0/20 | -- | -- | 0/20 | 0/20 | 0/20 | 0/20 | 8/20 b |
| -- Hair follicle epithelial necrosis | 0/20 | -- | -- | 0/20 | 0/20 | 0/20 | 0/20 | 4/20 a |
| Testes | ||||||||
| -- Arrested spermatogenesis | 0/20 | 0/20 | 0/20 | 10/20 b | -- | -- | -- | -- |
| -- Degeneration | 1/20 | 0/20 | 1/20 | 11/20 b | -- | -- | -- | -- |
| Epididymis | ||||||||
| -- Oligospermia | 0/20 | 0/20 | 0/20 | 11/20 b | -- | -- | -- | -- |
| Ovary | ||||||||
| -- Atrophy of corpora lutea | -- | -- | -- | -- | 0/20 | 0/20 | 7/20 b | 10/20 b |
a
p < 0.05 versus sex-matched vehicle control group.
b
p < 0.01 versus sex-matched vehicle control group.