Table 5.
Exposure-related microscopic lesions in dogs exposed to MSC
| Incidence in males (No. with lesion/No. evaluated) | Incidence in females (No. with lesion/No. evaluated) | |||||||
|---|---|---|---|---|---|---|---|---|
| MSC Dose (mg/kg/day) | 0 | 0.15 | 0.30 | 0.60 | 0 | 0.15 | 0.30 | 0.60 |
| Liver | ||||||||
| -- Peliosis hepatis | 0/4 | 0/4 | 0/4 | 1/4 | 0/4 | -- | -- | 0/4 |
| -- Vaculolar degeneration | 0/4 | 0/4 | 0/4 | 1/4 | 0/4 | -- | -- | 0/4 |
| -- Midzonal necrosis | 0/4 | 3/4 | 4/4 | 4/4 | 0/4 | -- | -- | 0/4 |
| Epidymis | ||||||||
| -- Degenerate spermatocytes | 1/4 | 2/4 | 4/4 | 4/4 | ||||
| Small Intestine | ||||||||
| -- Crypt dilatation | 0/4 | 2/4 | 2/4 | 2/4 | 0/4 | 1/4 | 3/4 | 3/4 |
| -- Crypt inflammation - acute | 0/4 | 2/4 | 1/4 | 1/4 | 0/4 | 1/4 | 3/4 | 3/4 |
| -- GALT – depletion (ileum) | 0/4 | 0/4 | 0/4 | 3/4 | 0/4 | 1/4 | 0/4 | 1/4 |
| -- GALT – lymphoid necrosis | 2/4 | 2/4 | 3/4 | 4/4 | 1/4 | 2/4 | 1/4 | 3/4 |
| Thymus | ||||||||
| -- Atrophy | 2/4 | 1/4 | 2/4 | 4/4 | 1/4 | 2/4 | 4/4 | 4/4 |