Table 1.

Summary of β-Catenin Mutations in DMH and IQ Tumors (All Target Organs*)

^*Rats were initiated with carcinogen for 5 wk; IQ was given in the diet (AIN-93) at a concentration of 0.03%, whereas DMH was injected s.c. once/wk (20 mg/kg body wt). Starting one wk after the last carcinogen treatment until the end of the study at 1 yr, rats were given CHL in the drinking water or I3C in the diet, at concentrations shown in the table. For details on the pathology of each tumor type, see [21].

^†Only codons affected by mutation are shown (except codon 31, in gray, to highlight the two CTGGA sequences commonly affected, dotted boxes).

^‡Number of mutations confirmed by sequencing/total tumors successfully amplified.

^§Total number of tumors with a mutation in the codon indicated.

^∥All groups combined for each carcinogen within the target organ shown. Colon tumor data were from a previous report [16].