Figure 1.

Novel modulators of yeast replicative life span (RLS). Replicative life span is significantly extended by deletion of 11 of 76 yeast ORFs in the RBH set, including the transcription elongation factor SPT4 (A), ATP-dependent metalloprotease AFG3 (B), inositol polyphosphate 5-phosphatase INP53 (C), ribosomal proteins RPL9A (D), and RPL19A (E), and translation initiation factors TIF4631 (F), TIF1 (G), and TIF2 (H). Deletion alleles of TOR1, RPL6B, and IDH2 have been previously shown to increase RLS (Kaeberlein et al. 2005). Mortality curves were generated from life span data in both the MATα and MATa mating types; the mean life span for each deletion strain and the experiment-matched wild-type (wt) control is given in parentheses in the key of each panel.