Table 1.

Genes that modulate longevity are conserved between worms and yeast

Replicative life span (RLS) was measured in viable deletion mutants of putative yeast orthologs (as defined by reciprocal best hit [RBH] analysis) of worm aging genes. This group of putative orthologs were found to be statistically enriched for genes that determine life span compared with a random set of yeast genes (expected frequency). RLS was also measured in yeast homologs (related proteins) of worm aging genes to account for redundancy of function within protein families and to identify novel modulators of longevity.

^aIncludes genes essential for viability and other genes not represented in the ORF deletion collection.