Figure 1.

(A) Ribbon representation of TT1426 (stereo view). In the core domain, the PRPP-binding motif is shown in magenta, the flexible loop is yellow, and the inserted region is green. The rest of the core domain is shown in red, and the hood is orange. (B) Sequence alignment of TT1426 and its homologs. The secondary structure for TT1426, shown above the sequences, is colored as in A. Filled magenta circles indicate the conserved PRPP-binding motif. RS00882 indicates Ralstonia solanacearum GMI1000; SMc01463, Sinorhizobium meliloti 1021; mll6596, Mesorhizobium loti MAFF303099; MA2685, Methanosarcina acetivorans C2A; aq_059, Aquifex aeolicus VF5; TVN1369, Thermoplasma volcanium GSS1; and Ta0227, Thermoplasma acidophilum DSM 1728.