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Two possibilities of Interleukin-6 receptor assembly. In both reaction pathways the first step is the formation of an IL-6/IL-6R complex. The second step is the association with one gp130 molecule and subsequent dimerization of this complex to form the final hexameric complex (A); the association with two gp130 molecules leading to the tetrameric complex, which then can bind another IL-6/IL-6R complex to form the hexameric complex (B).
