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Summary of mutational analyses of the pik cluster
| Mutant | Type of mutation | Target gene | Antibiotic production/intermediate accumulation
|
|
|---|---|---|---|---|
| Methymycin and neomethymycin | Pikromycin | |||
| AX903 | Insertion | pikAI | No/no | No/no |
| LZ3001 | Deletion/replacement | desVI | No/10-deoxymethynolide | No/narbonolide |
| LZ4001 | Deletion/replacement | desV | No/10-deoxymethynolide | No/narbonolide |
| AX905 | Deletion/replacement | pikAV | <5%/no | <5%/no |
| AX906 | Insertion | pikC | No/YC-17 | No/narbomycin |
