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. Author manuscript; available in PMC: 2008 Apr 3.
Published in final edited form as: Mutat Res. 2006 Jul 24;601(1-2):11–18. doi: 10.1016/j.mrfmmm.2006.05.026

Fig. 4.

Fig. 4

β-Catenin mRNA expression was correlated with cyclin D1, c-myc and c-jun mRNA levels in DMH-induced tumors. qPCR was used to examine DMH-induced tumors and normal mucosa for expression of three reported β-catenin/Tcf downstream targets, as well as AP-2α, a negative regulator of β-catenin/Wnt signaling [20]. In each case, mRNA expression was first normalized to the housekeeping gene, GAPDH. Open symbols (○), tumors containing WT β-catenin; closed symbols (●), tumors with mutant β-catenin.