Figure 3.
Cavity in the SycT dimerization interface. A polar cavity is enclosed in the dimerization interface of SycT (crystal form #1, cavity as pink surface model and blue side chains of residues Trp47, Pro70, Ala71, His72, Val73, Leu83, Trp84, Ser85, and Ser88, and red side chain for Gln86). Both Val90 residues (green) shield the cavity from the outside. In contrast, the cavity in SycH is accessible and possesses a positive charge (Arg80, red side chain).