Figure 3.

Freezing response (mean/min) before and after foot shock during contextual fear conditioning (CFC) training (A) and during 5 minutes (mean/min) of CFC test (B). Adrenocorticotropic hormone (ACTH) (C) and corticosterone (CORT) (D) plasma levels were obtained 15 minutes after CFC test session of paradoxical sleep deprivation (PSD) (96 hours of PSD - circles, full line) and CTL (control - squares, dotted line) animals, which received an acute injection of MET (metyrapone - dark squares/circles) or VEH (vehicle - open squares/circles) 90 minutes before training. *Different from CTL group (analysis of variance [ANOVA] group effect). ^¥Different from the other groups (analysis of variance group × treatment interaction effect). n = 8/group.