Figure 2.

Critical regions of contrast hierarchical alignments showing various family-specific constraints within CMGC kinases. CMGC kinases (operationally defined as protein kinases with either an arginine or a lysine at the CMGC-arginine position) constitute the background sequence set for each alignment. See legend to Figure 1 ▶ for a further description of alignment highlighting and notation. See Materials and Methods for sequence identifiers. For each alignment, the sequences displayed are from distinct phyla. See text for details. (A) MAP-specific constraints. (B) CDK-specific constraints. (C) GSK-specific constraints. (D) SRPK-specific constraints. (E) DYRK-specific constraints. (F) CK2-specific constraints.