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. 2004 Aug;13(8):2029–2044. doi: 10.1110/ps.03390504

Figure 8.

Figure 8.

The Hsc70/auxilin complex showing bound ADP + Pi relative to the J-domain and SBD, and showing that the Hsc70 C-terminal “lid” domain and GrpE protein are compatible with the model structure. Auxilin is shown in violet, with the clathrin binding region shown in purple except for the clathrin binding helix, which is shown in pink. The ATPase domain is shown in blue, and the bound nucleotide (ADP + Pi) is shown in red. The SBD, which is shown in its HPD-loop/D152 docking site, is green with bound peptide in red. The lid domain is shown in closed form (yellow) and a hypothetical open form (orange), modeled by superposing lid X-ray structure backbone atoms of residues 518–526 (PDB code 1DKX; Zhu et al. 1996) with the corresponding NMR structure residues (PDB code 7HSC; Morshauser et al. 1999). The GrpE protein was placed by superposing the DnaK ATPase/GrpE complex (PDB code 1DKG; Harrison et al. 1997) on the Hsc70 ATPase domain.