TABLE 2.
AGE-modified Peptides Observed by MALDI-TOF-MSa
| Peptide observed (residue nos.) | Modification | Theoretical mass MH+ (m/z) | Measured mass MH+ (m/z) | ▵M (ppm) | Protein source |
| IVKWDR (112-117) | Schiff base or AP | 978.49 | 978.56 | −70 | Human β2M |
| TPKIQVYSR (24-32) | Schiff base or AP | 1253.64 | 1253.76 | −120 | Human β2M |
| DEYACRVNHVTLSQPK (96-111) | AFGP | 2129.98 | 2130.13 | −150 | Human β2M |
| IVKWDR (112-117) & TPKIQVYSR (24-32) | Crossline | 2159.19 | 2159.20 | −10 | Human β2M |
| IVKWDR (112-117) & IQVYSRHPAENGK (27-39) | Pentosidine | 2371.27 | 2371.27 | 0 | Human β2M |
| KAVWHK (3584-3589) | CML | 826.45 | 826.13 | 320 | Rat RyR2 |
| VDVSRISER (1607-1615) | Imidazolone B | 1202.60 | 1202.71 | −110 | Rat RyR2 |
| MSKAAISDQER (3439-3449) | Imidazolone B | 1377.60 | 1377.90 | −300 | Rat RyR2 |
| AALDFSDAREK (4677-4687) | Pyrraline | 1330.63 | 1330.82 | −190 | Rat RyR2 |
| ANACNSVIKQLMK (468-480) | AFGP | 1689.75 | 1689.81 | −60 | Rat SERCA2a |
| KEFTLEFSR (481-489) | AFGP | 1426.60 | 1426.72 | −120 | Rat SERCA2a |
| KSVQR (135-139) & VPADIRLTSIK (159-169) | Pentosidine | 1887.10 | 1886.86 | 240 | Rat SERCA2a |
| KSVQR (135-139) & AFTGREFDELSPSAQR (651-666) | Pentosidine | 2485.24 | 2485.14 | 100 | Rat SERCA2a |
aModified residues in bold and underline.