Table 1.
Inhibitors of P. mevalonii HMG–CoA reductase
| Compound tested | Ki (mM) | Ki/Km |
| Mevalonate (substrate) | 0.26 (Km) | |
| β-Hydroxybutyrate | 0.8 | 3.1 |
| Acetoacetate | 3.0 | 12 |
| 3-Hydroxy-3-methylglutarate | 4.5 | 17 |
| γ-Hydroxybutyrate | 35 | 135 |
The listed compounds were tested as inhibitors of reaction 2, the oxidative acylation of mevalonate to HMG–CoA. Inhibition was in all cases competitive with mevalonate. The Km value for mevalonate is from Rodwell et al. (2000). Ki values were calculated from the data of Figure 2 ▶.