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. 2004 Jun;13(6):1693–1697. doi: 10.1110/ps.03597504

Table 2.

Inhibition of P. mevalonii HMG–CoA reductase by Lovastatin

Reaction Varied substrate Inhibition Ki (mM)
1 HMG-CoA Competitive 0.53
1 NADH Non-competitive 16
2 Mevalonate Competitive 0.28
2 NAD+ Non-competitive 35

Lovastatin was tested as an inhibitor of the oxidative acylation of mevalonate to HMG-CoA, reaction 2, and of the reductive deacylation of HMG-CoA to mevalonate reaction 1: Ki values were calculated from the data of Figure 3 ▶.