Sequence alignment of E3 rRNase with known and putative rRNase domains. Fully conserved positions are highlighted in dark gray and semiconserved in light gray. Asterisks denote residues identified as important for cytotoxicity. Sequences were obtained from the NCBI: E3 (gi_147 19502), E4 (gi_1071871), E6 (gi_116063), Ccl (gi_6176538), Lum1A (gi_16416909), Pflu4757 (gi_23062707), CV2871 (gi_34498326), Haso120001 (gi_32029964), HecA (gi_23573417).