Table 2.

Biochemical and structural data of calcium binding proteins

	Characteristic motif	Structural feature	Involved amino acids	Conformational change after Ca2+-binding	Function (with Ca2+)
MTH1880	—	Beta-sheets and loops	D, E, S, L	N	Calcium buffer
Gelsolin	—	Beta-sheet, loop and helix	D, G, P	Y	Actin-binding
Calmodulin	EF-hand	Helix-loop-helix	D, E, Q, N, T	Y	Calcium sensor
Thermitase	Subtilisin family	Loops	D, Q, R, S, T, A, Y, V, I	Y	Thermostability
Crystallin	Greek key	Beta-sheets	D, E, N, Q, K, S, Y	N	Calcium buffer

Source: structural features and characters are reported as followed: Gelsolin (PDB: 1SVY, 1D0N), Calmodulin (PDB: 3CLN), Thermitase (PDB: 1THM, reference cited in text: 17), γ-Crystallin (PDB: 1HDF).