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Inhibition of Gqα stimulation of Btk kinase activity by GST-THSH3. Peptide substrate phosphorylation by Gqα-GTPγS-stimulated Btk (11) was measured in the absence or presence of increasing concentrations of GST (•), GST-THSH3 (■), or GST-PH (▴). Although preincubation of Gqα with GST-THSH3 reduced the ability of Gqα to stimulate Btk, preincubation with GST or GST-PH had no significant effect. Data are from one of three similar experiments.
