Table 3.

Mutation rates at the hom3-10 and lys2-Bgl hotspots

Strain	Mutation rate
	hom3-10	lys2-Bgl
	T646–652	A364–369	C401–404	T417–419
Wild type	9.5  ×  10−9 (1.0)	0.2  ×  10−8 (1.0)	0.13  ×  10−8 (1.0)	0.05  ×  10−8 (1.0)
mlh3	3.7  ×  10−8 (3.9)	1.1  ×  10−8 (5.5)	0.44  ×  10−8 (3.4)	0.04  ×  10−8 (0.9)
msh3	N.D.	1.1  ×  10−8 (5.5)	0.18  ×  10−8 (1.4)	<0.04  ×  10−8 (<1)
mlh3 msh3	N.D.	1.4  ×  10−8 (7.0)	0.5  ×  10−8 (3.8)	0.15  ×  10−8 (3.0)
msh6	9.1  ×  10−8 (8.6)	0.23  ×  10−8 (1.2)	0.23  ×  10−8 (1.8)	0.76  ×  10−6 (15.2)
mlh3 msh6	8.2  ×  10−7 (86)	2.9  ×  10−8 (14.5)	0.6  ×  10−8 (4.6)	0.23  ×  10−6 (4.6)

Mutation rates were recalculated based on the frequency of occurrence of frameshifts at the indicated sites. N.D., not determined (see Table 2 for gross mutation rates at this site).