Figure 6.
Proposed mechanism by which T cell–dependent inflammation promotes atherosclerosis but is dampened by TGF-β (a). The lack of functional TGF-β receptors on T cells abrogates the modulatory action of this cytokine, leading to aggravated atherosclerosis in E0 × CD4dnTβRII mice (b). TGF-βR, TGF-β receptor.