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Southern blot analysis of DNA from three patients specimens of normal squamous esophagus (N) and esophageal adenocarcinoma (T) hybridized with CTSB, FDFT1, and NAT-1 cDNA probes demonstrating 20-fold amplification of CTSB and FDFT1 genes in tumor (D06). The NAT-1 gene was not amplified in any of the 66 esophageal adenocarcinomas analyzed.
