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Activation (n-fold) of various kinase-substrate combinations by HPV E7a
| Kinase-substrate combination | Increase (n-fold) in kinase activity with E7 addition |
|---|---|
| Cyclin A-CDK2::histone H1 | 26 |
| Cyclin E-CDK2::histone H1 | 13 |
| Cyclin E-CDK2::Rb | 1.9 |
| Cyclin B-CDC2::histone H1 | 1.0 |
| p25/CDK5::histone H1 | 4.5 |
| MAP kinase I::myelin basic protein | 1.1 |
Activation of kinase-substrate combinations is expressed as increase (n-fold) over controls that received no E7.
