TABLE 2.
Activation (n-fold) of cyclin A-CDK2 histone and pRb kinase activity by HPV E7a
Form of E7 | Kinase activity of:
|
|
---|---|---|
Histone H1 | pRb | |
16E7b | 14.0 | NDc |
GST-16E7 | 18.2 | 2.3 |
GST-31E7 | 12.6 | 1.6 |
GST-6bE7 | 15.8 | 2.2 |
Kinase activity is expressed as increase in kinase activity over controls not receiving E7.
HPV16 E7 purified away from GST tag.
Activity not determined.