Figure 4.

Influence of MBP-specific latent TGF-β1-transduced and untransduced cloned BALB/c T cells on actively induced EAE in SJL × BALB/c mice. Mice (SJL × BALB/c) were immunized with PLP 139–151 in CFA and developed EAE starting on day 15 if left untreated (n = 15; •). Mice receiving 3 × 10⁶ recently activated MBP-specific, TGF-β1-transduced cloned T cells on day 12 (n = 13; ■) had delayed and significantly less severe EAE throughout the course of the disease than did control mice not receiving cells or mice receiving 3 × 10⁶ MBP-activated, untransduced T cells on day 12 (n = 14; ▴). ∗, P < 0.05; ∗∗, P ≤ 0.01; ∗∗∗, P ≤ 0.001; bars = SE.