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Protective effect of MBP-activated, TGF-β-transduced T cells transferred during development of EAE. Mice were induced to develop EAE as in Fig. 4. MBP-activated, TGF-β-transduced T cells (3 × 106 per recipient) were transferred into groups of five mice each on day 15 (■) or on day 18 (▴). EAE severity was significantly reduced as compared with the mice not receiving cells (•) only in the group receiving cells on day 15. ∗∗, P ≤ 0.01.
