Table 1.
The predicted binding site positions
| OR segment position | Alignment position | Other GPCR | GPCR amino acid |
| TM2 13 | 86 | Human endothelin-1 receptor precursor (ET-A) | Y:129 |
| TM3 4 | 115 | Rat muscarinic m1 receptor | L:102 |
| TM3 7 | 118 | Rat muscarinic m1 receptor | D:105 |
| TM3 8 | 119 | Rat muscarinic m3 receptor | Y:148 |
| TM3 11 | 122 | Human dopamine D3 receptor | C:114 |
| TM3 12 | 123 | Rat muscarinic m1 receptor | N:110 |
| TM3 15 | 126 | Rat muscarinic m1 receptor | V:113 |
| TM3 16 | 127 | NA | |
| TM4 12 | 167 | Bovine rhodopsin | A:164 |
| TM4 16 | 171 | Human dopamine D2 receptor | S:267 |
| TM4 19 | 174 | Rat muscarinic m3 receptor | P:201 |
| EL2-1 | 193 | cholecystokinin type B (CCKB) receptor | Q:204 |
| EL2 2 | 196 | cholecystokinin type B (CCKB) receptor | H:207 |
| TM5 2 | 214 | Human α2A adrenergic receptor | V:197 |
| TM5 6 | 218 | Human α2A adrenergic receptor | C:201 |
| TM5 9 | 221 | Human α2A adrenergic receptor | S:204 |
| TM5 10 | 222 | Rat 5HT2A serotonin receptor | F:243 |
| TM6 12 | 288 | Bovine rhodopsin | F:261 |
| TM6 15 | 291 | Rat type-1B angiotensin II receptor | S:252 |
| TM7 5 | 321 | Human neurokinin-1 (substance P) receptor | I:290 |
| TM7 6 | 322 | Human dopamine D3 receptor | T:369 |
| TM7 9 | 325 | Rat muscarinic m1 receptor | C:407 |
The 22 predicted binding site positions in OR proteins with their numbering within the various protein segments and the alignment. The “other GPCR” column lists non-OR GPCRs in which the corresponding residue was linked to ligand binding, and the “GPCR amino acid” column gives the enumeration of this residue in the original protein sequence. NA indicates that no functional residue in a non-ORGPCR was found to align against the position. Information regarding functional residues was derived from the tiny GRAP mutant database (Edvardsen et al. 2002) via the GPCRDB graphical interface (Horn et al. 2001), and from (Baldwin 1994; Ji et al. 1995; Silvente-Poirot and Wank 1996; Lu and Hulme 1999; Ballesteros et al. 2001; Shi and Javitch 2002), and was matched to the prediction using the alignment in Figure 2A ▶.