Table 2.
OR residues predicted by docking studies to participate in odorant binding
| Location in OR model | Alignment position | Predicting studies | Predicted by the present study |
| TM3 | 115 | (Floriano et al. 2000) | Yes |
| TM3 | 118 | (Floriano et al. 2000; Vaidehi et al. 2002) | Yes |
| TM3 | 119 | (Floriano et al. 2000) | Yes |
| TM3 | 122 | (Floriano et al. 2000) | Yes |
| TM3 | 123 | (Floriano et al. 2000; Vaidehi et al. 2002) | Yes |
| TM3 | 126 | (Vaidehi et al. 2002) | Yes |
| TM4 | 174 | (Singer 2000; Vaidehi et al. 2002) | Yes |
| EL2 | 178 | (Floriano et al. 2000) | No |
| EL2 | 182 | (Floriano et al. 2000) | No |
| In the fifth helix but outside TM5 | 210 | (Floriano et al. 2000) | No |
| TM5 | 214 | (Afshar et al. 1998; Singer 2000) | Yes |
| TM5 | 215 | (Floriano et al. 2000; Singer 2000) | No |
| TM5 | 216 | (Floriano et al. 2000) | No |
| TM5 | 218 | (Singer 2000) | Yes |
| TM5 | 219 | (Floriano et al. 2000) | No |
| TM6 | 286 | (Vaidehi et al. 2002) | No |
| TM6 | 289 | (Singer 2000) | No |
| TM6 | 290 | (Floriano et al. 2000) | No |
| TM6 | 293 | (Floriano et al. 2000; Singer 2000) | No |
| EL3 | 306 | (Floriano et al. 2000) | No |
| TM7 | 318 | (Floriano et al. 2000) | No |
| TM7 | 322 | (Singer 2000) | Yes |
Residues predicted by docking studies (Afshar et al. 1998; Floriano et al. 2000; Singer 2000; Vaidehi et al. 2002) are listed together with their location in the OR structure, as inferred by homology from the rhodopsin crystal structure (Palczewski et al. 2000), and an indication of whether they were predicted by our analysis. The “Location in OR model” provides the location of the residues in the context of the homology model generated by the present study (Fig. 3 ▶); the “Alignment position” columns specifies the position of the residues in the alignment in Figure 2A ▶; and the “Predicting studies” column indicates which studies suggested that the residue participates in odorant binding.