Table 5.

Solvation parameters determined for different types of atoms (see Materials and Methods)

	σ (cal/mole Å2)
Combination of media	Nsolutea	C-aliph	C-arom	N	O	S
Water–decadiene	16	13 ± 3b	19 ± 2	−53 ± 3	−57 ± 3
Water–hexadecene	16	13 ± 4b	19 ± 2	−55 ± 4	−63 ± 4
Water–hydrocarbons	34	22 ± 1	18 ± 1	−66 ± 2	−72 ± 2	−13 ± 7
Water–lipidc		25	19	−55	−63	−13
Water–proteind		19	7	−21	−66	−1
Lipid–proteine		−6	−12	34	−3	12

^a Number of solutes applied for fitting.

^b These values must be disregarded, because the solutes, whose transfer energies were applied for fitting, had few aliphatic carbons.

^c Water–lipid parameters were selected as described in the text.

^d Parameters obtained from protein engineering data (Lomize et al. 2002).

^e The differences of values from two upper rows.